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| |
Hazard-Ratio
|
P-Value
|
|---|
|
Age group
|
|
< 40
|
Reference
| |
|
[40–50[
|
0.80 (0.72; 0.90)
|
< 0.0001
|
|
[50–60[
|
0.68 (0.60;0.76)
|
< 0.0001
|
|
[60–70[
|
0.52 (0.44;0.62)
|
< 0.0001
|
|
> =70
|
0.34 (0.27; 0.44)
|
< 0.0001
|
|
Gender
|
|
Female
|
reference
| |
|
Male
|
0.99 (0.91; 1.07)
|
0.7267
|
|
Regions
|
|
Ile-de-France
|
1.31 (1.19; 1.44)
|
< 0.0001
|
|
GrandEst
|
1.29 (1.14; 1.47)
|
< 0.0001
|
|
Other French metropolitan regions
|
reference
| |
|
Living Area
|
|
Rural
|
Reference
| |
|
< 20,000 inhab.
|
1.07 (0.93; 1.22)
|
0.3629
|
|
20–000-100,000 inhab.
|
1.14 (1.00; 1.30)
|
0.0471
|
|
> 100,000 inhab.
|
1.15 (1.02; 1.29)
|
0.0241
|
|
Household size and composition
|
|
Nb persons (incl. participant)
| | |
|
1
|
Reference
| |
|
2
|
0.95 (0.85; 1.06)
|
0.3405
|
|
3 or +
|
1.00 (0.87; 1.16)
|
0.9603
|
|
Nb children (< 18 yrs)
| | |
|
0
|
Reference
| |
|
1 or +
|
1.28 (1.13; 1.45)
|
0.0001
|
|
BMI (kg/m2)
|
|
< 18.5
|
1.04 (0.85; 1.27)
|
0.6916
|
|
[18.5; 25[
|
Reference
| |
|
[25; 30[(overweight)
|
1.17 (1.07; 1.27)
|
0.0005
|
|
> =30 (obese)
|
1.41 (1.25; 1.58)
|
< 0.0001
|
|
Professional activity before lockdown
|
|
Student
|
1.01 (0.71; 1.44)
|
0.9620
|
|
Working
|
Reference
| |
|
Looking for a job
|
1.05 (0.86; 1.27)
|
0.6618
|
|
Retired
|
0.86 (0.72; 1.03)
|
0.1057
|
|
Not working due to health conditions
|
1.30 (0.96; 1.77)
|
0.0894
|
|
No professional activity (house wife or husband)
|
0.89 (0.68; 1.16)
|
0.3773
|
|
Essential job position
|
|
Health care worker (Y vs N)
|
1.18 (1.00; 1.40)
|
0.0535
|
|
Other essential job (Y vs N)
|
1.01 (0.90; 1.14)
|
0.8922
|
|
Chronic diseases (Y vs N)
|
|
Asthma, COPD, other resp. diseases
|
1.41 (1.24; 1.60)
|
< 0.0001
|
|
Anxiety, depression
|
1.31 (1.08; 1.58)
|
0.0065
|
|
Other
|
1.22 (1.08; 1.37)
|
0.0013
|
- a with stratification on the cohort. 6567 (6%) participants excluded from the multivariable model due to missing values including 190 with CLS; educational level was not significantly associated with CLS when included in the multivariable model (high school degree or undergraduate versus <high-school degree, P = 0.7743; graduate or doctorate versus <high-school degree, P = 0.6299), and was not kept in the final model due to missing information on this covariate in the E4NG2 cohort. To avoid overfitting Positive RT-PCR in another household member was not entered in the model. However, results were unchanged when this variable was entered (not shown)
