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Table 2 Sensitivity (SENS), specificity (SPEC), positive and negative predictive values (PPV and NPV), and numbers of false negative (FN) and false positive results (FP) when test strips or flow cytometry was used to separate relevant bacteriuria from bacteriuria, contamination or no culture growth of all samples using different cut-off values. Test performances for different definitions of relevant bacteriuria (≥ 105, ≥ 104 and ≥ 103, respectively) are listed. Pos.: positive test strip result

From: Accuracy of urine flow cytometry and urine test strip in predicting relevant bacteriuria in different patient populations

Bacterial growth (CFU/ml) Method Test Cut-off SENS (%) SPEC (%) PPV (%) NPV (%) FN FP
≥ 105 Test strip Nitrate pos. 35.8 97.9 84.9 82.0 7662 758
   Leuk. esterase pos. 81.5 68.1 46.1 91.7 2211 11,372
  Flow cytometry Leukocyte count 10 91.8 46.2 36.3 94.4 981 19,190
    50 75.9 74.7 50.1 90.2 2876 9028
   Bacteria count 50 95.8 67.8 49.9 98.0 497 11,471
    250 87.2 85.6 66.9 95.2 1528 5137
≥ 104 Test strip Nitrate pos. 28.4 98.1 87.8 73.8 11,129 613
   Leuk. esterase pos. 75.0 70.5 55.2 85.3 3892 9441
  Flow cytometry Leukocyte count 10 87.2 48.2 45.0 88.6 1986 16,583
    50 68.8 76.9 59.2 83.6 4844 7384
   Bacteria count 50 86.3 70.4 58.6 91.4 2122 9484
    250 72.4 86.6 72.4 86.6 4295 4292
≥ 103 Test strip Nitrate pos. 27.2 98.1 88.2 72.2 11,836 592
   Leuk. esterase pos. 74.1 71.1 57.2 84.1 4213 9034
  Flow cytometry Leukocyte count 10 86.8 48.8 46.8 87.7 2149 16,018
    50 68.1 77.6 61.2 82.4 5197 7009
   Bacteria count 50 83.8 70.4 59.6 89.3 2628 9262
    250 69.6 86.5 72.9 84.6 4949 4218