Neonatal prophylaxis with antibiotic containing ointments does not reduce incidence of chlamydial conjunctivitis in newborns

Table 1 Characteristics of excluded studies

Study, year, location, ref. #	Prospective	Was study comparative?	Ocular prophylaxis Preparations	Prenatal screening for C. trachomatis	Number of Infants	Infants followed prospectively	Only Infants with conjunctivitis tested for C. trachomatis	All infants seen prospectively, and tested for C. trachomatis in eye and NP
1. Laga (1988) [15], Kenya	Yes	Yes	Silver nitrate Tetracycline	No*	1233 1499	Yes	Yes	Yes
2. Chen (1992) [16], Taiwan	Yes	Yes	Silver nitrate Tetracycline Erythromycin No prophylaxis Erythromycin twice	No	1082 1156 1163 1143 425	No	No	No
3. Rours (2006) [17], South Africa	Yes	No#	Tetracycline	Yes	77	Yes	Yes	Yes
4. Ali (2007) [18], Iran	Yes	Yes	Betadine Erythromycin No prophylaxis	No	110 110 110	Yes	Yes	No
5. Matinzadeh (2007) [19], Iran	Yes	Yes	Erythromycin No prophylaxis Normal saline	No	320 337 335	Yes	Yes	Yes
6. Ramirez-Ortiz (2007) [20], Mexico	Yes	Yes	Povidone-iodine vs. chloramphenicol	No	2004	Yes	Yes	Yes
7. David (2011) [21], Israel	Yes	No	Povidone iodine vs. tetracycline	No	394	Yes	Yes	No
8. Alexandre (2015) [22], Angola	No	No	Povidone-iodine vs. no prophylaxis	No	317	No	No	No

* Women identified intrapartum, results not available at delivery. # No comparative arm
1% silver nitrate drops
1% tetracycline ophthalmic ointment
0.5% erythromycin ophthalmic ointment
2.5% povidone-iodine drops

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